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Laboratory Capabilities

Based on our current laboratory instrumentation, we have the ability to perform the following measurements. Other capabilities exist with our consortium members. Please contact us for specific details.

  • Low Frequency Electron Paramagnetic Resonance Spectroscopy
    LFEPR spectroscopy of objects as large as 15 cm in diameter and 200 cm (yes 2 m!) long focusing on a 2 cm diameter, 5 cm deep volume at the surface. LFEPR spectroscopy of 1.5 cm diameter, 2 cm long objects at operating frequencies between 100 and 500 MHz.

  • Diffusion Coefficient Measurement
    Isotropic Anisotropic
    Nuclei H-1, C-13, P-31, N-14 H-1 H-1
    D 10-4 to 10-8 cm2/s 10-4 to 10-6 cm2/s 10-4 to 10-8 cm2/s
    Sample Size 5 mm 70 cm 5 mm
    Temperature -50 to 200 oC RT -50 to 200 oC

  • Imaging
    Field Strength (Bo) 50 mT 1.5 T 3 T 7 T 11.7 T
    Field of VIew (FOV) 7 cm 4 - 40 cm 4 - 40 cm 4.5 mm 4.5 mm
    Nuclei* H H H H H
    Pixel Size 120 μ 80 μ 80 μ 20 μ 20 μ
    Sequences SE SE, Grad. Echo, FSE, IR, MRA, D, EPI SE, Grad. Echo, FSE, IR, MRA, D, EPI GE, SE, IR GE, IR
    * Other nuclei available on request.

  • MRI and NMR Radio Frequency Coil Tuning
    Tune NMR imaging or spectroscopy coil.
    Frequency Range: 5 to 500 MHz
    Impedance: 50 or 75 Ohms

  • MRI and NMR Radio Frequency Coil Construction
    Design and build a radio frequency RF coil for NMR imaging or spectroscopy in the 5 to 500 MHz range.

  • High Resolution NMR Spectroscopy
    Field Strength (Bo) 7 T (300 MHz) 11.7 T (500 MHz)
    Sample Size 5 mm 5 mm
    Nuclei* H-1, C-13, P-31, N-15 H-1, C-13, P-31, N-15
    Temperature -50 to 200 oC -150 to 150 oC
    1D and 2D Pulse Sequences Bruker Library Bruker Library
    Phase Liquid Liquid
    * Others are available depending on sensitivity.

  • Radio Frequency Magnetic Field Mapping
    Map the transmit and receive radio frequency magnetic field distribution in an MRI coil.
    Spatial resolution = 0.004 of largest coil dimension
    Field resolution = 0.01 of largest field value

  • Spin-Lattice Relaxation Time (T1) Measurement
    Analysis: monoexponential, biexponential, multiexponential, and principal component
    Field Strength (Bo) 50 μT 1-18 mT* 0.75 T 1 T 1.5 T 7 T 11.7 T
    Maximum* 5 s 5 s 10 s 10 s 3 s 10 s 10 s
    Minimum* 50 ms 50 ms 10 ms 10 ms 100 ms 10 ms 10 ms
    Nuclei H H H H H H + others H + others
    Temperature RT RT RT 25 oC 5 to 50 oC -50 to 200 oC -150 to 150 oC
    Analysis ROI ROI ROI ROI ROI & Image ROI ROI
    * - Signal strength dependent
    ROI - Region of Interest

  • Spin-Spin Relaxation Time (T2) Measurement
    Analysis: monoexponential, biexponential, multiexponential, and principal component
    Field Strength (Bo) 50 μT 0.75 T 1.5 T 7 T 11.7 T
    Maximum* 1 s 1 s 1 s 1 s 1 s
    Minimum* 35 ms 1 ms 10 ms 1 ms 1 ms
    Nuclei H H H H + others H + others
    Temperature RT RT 5 to 50 oC -50 to 200 oC -150 to 150 oC
    Analysis ROI ROI ROI & Image ROI ROI
    * - Signal strength dependent
    ROI - Region of Interest

  • Dielectric Constant & Resistivity
    Measure the relative dielectric constant and resistivity of liquids and gells.
    Frequency Range = 100 kHz - 200 MHz
    Minimum Sample Volume = 5 ml

  • MRI Phantom Design and Prototyping
    We specialize in custom engineered phantoms to meet specific QC imaging needs.
    Some examples of our work include:
    Phantom Features
    Relaxation Time Fixed T1 and T2 values.
    Resolution Measure resolution and PSF in 3D without repositioning.
    Diffusion Water based, selectable D values between DWater and 0.25 DWater.
    fMRI Switchable T2 value.
    Fat Sat Variable fat-to-water ratio solution for fat-saturation imaging.
    Digital Determine segmentation accuracy.

 


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Magnetic Resonance Laboratory
Center for Imaging Sciecne
Rochester Institute of Technology
54 Lomb Memorial Drive, Rochester, NY 14623-5604

voice: 585 475-2904     fax: 585 475-5988     e-mail: jphsch@rit.edu


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